Sir Kevan Collins will step down as chief executive of the Education Endowment Foundation later this year.
Collins, who has led the organisation for eight years, will remain in post until August, before moving to a part-time role to support a new chief executive.
Sir Peter Lampl, EEF chairman, said: “Under Kevan’s leadership, the EEF has become a widely respected and influential organisation within the UK and globally.
“Not only has it funded and evaluated high potential programmes that have reached hundreds of thousands of young people, it has also put evidence firmly on the agenda of teachers, headteachers and policy makers.”
Collins added he leaves the foundation with a “strong sense of pride and gratitude”.
“I’m proud of what we have achieved and that we are making a significant difference by bringing evidence to inform and support teachers and school leaders as they strive to deliver the very best education for all children in our schools.”
But he said there is “much more to do to tackle the educational disadvantage that scars our education system and denies the potential of so many children.
“However, through the work of the EEF we have helped to illuminate the issue and identify approaches that make a real difference.
“I have every confidence that the organisation will continue to thrive in the coming years.”
Collins added he will pursue other education-related interests, including working with teachers and school leaders around the world.